Racemization of compounds containing an asymmetric quaternary carbon atom

  • Inventors:
  • Assignees: Merck & Co Inc
  • Publication Date: March 22, 1967
  • Publication Number: GB-1062334-A


Compounds having a quaternary asymmetric carbon atom bonded to a nitrile group and to a carboxylic acylamino group containing no base-sensitive substituents are racemized by treatment with at least 0.01 mole, per mole of said compound, of a base capable of removing the hydrogen atom from the amide nitrogen atom. The compounds may be prepared by reacting together the appropriate a -amino-nitrile and the acid anhydride, the former reactant being obtained by reacting the appropriate ketone with ammonium cyanide.




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